Four members of the Biophysical Society of China (BSC) are among the winners of the innovation award of the 15th C. C. Tan Life Science Award, as announced on Dec 10, in East China's Shanghai.
They are: Sun Jinpeng, professor, doctoral supervisor and executive vice-president of the Advanced Medical Research Institute at Shandong University; Xiao Bailong, research fellow vice-dean of the School of Pharmaceutical Sciences at Tsinghua University and a senior researcher at the Tsinghua University-Peking University Joint Center for Life Sciences; Zhang Yan, professor, vice-dean of the School of Basic Medical Sciences and deputy director of the Innovative Drug Research Center at Zhejiang University; and Zhou Dawang, professor, vice-president of Xiamen University and a council member of the BSC.
Rao Zihe, honorary president of the BSC, presides over the award ceremony of the 15th C. C. Tan Life Science Award.
The award was granted to 17 scientists, including two achievement award winners, three clinical medicine award winners, two industrialization award winners and 10 innovation award winners.
Profiles of the winners
Sun has studied GPCR ligands and their interaction mechanisms, the role GPCR plays in diabetes and other metabolic diseases, as well as in reproduction, hearing, kidney diseases and bone development and targeted drug discovery, the pharmacological theory of biased signal transduction of GPCR and transmembrane signal transduction in tissue remodeling.
Xiao has studied the dynamic mechano-gating mechanism and regulation system of Piezo channels and their biophysical property-based physiological and pathophysiological roles. He has developed drugs and technologies targeting Piezo channels and identified novel mechano-gated ion channels and their regulatory proteins.
Zhang’s major research interest is in the screening of biased GPCR modulators and studies on the Cryo-EM of effector protein complexes, RAMP regulation of GPCR in substrate specificity recognition, the role GPCR plays in the nervous and immune systems and the development and application of high-resolution cryo-ET.
Zhou has been engaged in the study of the biological functions and regulatory mechanism of the Hippo signaling pathway. He has also done research on the pathogenesis of diseases such as immune disorders and cancers caused by an uncontrolled Hippo pathway, and targeted intervention strategies against them. His research has focused on the repair and regeneration of damaged tissues and organ size regulation.